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Home - Products - Chromatin/Epigenetic - COX - Amtolmetin guacil

Amtolmetin guacil

CAS No. 87344-06-7

Amtolmetin guacil( —— )

Catalog No. M27126 CAS No. 87344-06-7

Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Amtolmetin guacil
  • Note
    Research use only, not for human use.
  • Brief Description
    Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
  • Description
    Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
  • In Vitro
    Amtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin, HY-B1799) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes.
  • In Vivo
    Animal Model:Male Wistar ratsDosage:50 mg/kg Administration:p.o.; single dosage Result:Pharmacokinetic Parameters of Amtolmetin guacil in male Wistar rats.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    USP30
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    87344-06-7
  • Formula Weight
    420.465
  • Molecular Formula
    C24H24N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.
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